Predictive Genomics
& Wellness
Shifting healthcare from reactive to proactive. Leveraging the largest Thai genomic databases, T2Gen provides rigorously validated Polygenic Risk Scores (PRS) calibrated specifically for the Thai demographic. We equip premium wellness centers with the tools to predict and prevent Non-Communicable Diseases (NCDs) before they manifest.
SNP Array
Service
We provide high-quality SNP array analysis using the GeneTitan™ Axiom™ platform for accurate SNP genotyping and point mutation detection. This service supports applications such as variant screening, sample authentication, and population-level genetic studies.
Our workflow includes DNA QC, array processing, genotype calling, and variant analysis using validated Axiom™ pipelines. Results are delivered as secure technical reports, including SNP calls, QC metrics, and mutation-level summaries in VCF file format (no clinical interpretation)
PRS Analysis
Service
We offer a comprehensive PRS analysis service to assess genetic predisposition to complex traits and diseases using validated polygenic models. Our service includes:
• Calculation of polygenic risk scores and generation of customized reports based on customer-selected polygenic models.
• Validation of polygenic scores for targeted phenotypes using data from the Polygenic Score (PGS) Catalog or other relevant databases, tailored to the selected population or dataset.
• Investigation of polygenic risk in selected populations using a case–control study design, providing population-specific insights into genetic risk.
• Assessment of genotyping platforms for polygenic risk scoring, offering guidance on selecting the optimal SNP array or sequencing panel and the most appropriate PRS model for specific populations and study objectives.
This service is designed to support researchers and clinicians in integrating polygenic risk into research, clinical decision-making, and personalized medicine.
Imputation
Service
Thailand has launched a national genotype imputation service designed specifically for Thai and Southeast Asian genomes, enabling researchers to reconstruct near whole-genome–scale data from standard SNP arrays with high accuracy. Built on a Thai reference panel of more than 17,000 whole-genome sequences, the platform delivers markedly improved performance—especially for rare variants—compared with global reference panels. Benchmarking shows that optimal accuracy is achieved with approximately 13,000 Thai genomes, balancing precision, speed, and cost. The web-based service supports PLINK and VCF formats and is ready for applications in pharmacogenomics, GWAS, polygenic risk scores, and precision medicine.
